Unlock the Secrets of Cellular Biology

Exploring the Complexities of Centrosome and Cilia Biology

About the CCB lab
Welcome to the Laboratory of Centrosome and Cilia Biology! Our state-of-the-art laboratory is dedicated to the study of centrosomes and cilia, crucial organelles involved in various cellular processes. Led by a team of passionate researchers, we are committed to unraveling the mysteries of centrosome and cilia biology, paving the way for groundbreaking discoveries and potential therapeutic applications. Explore our website to learn about our ongoing projects, recent publications, and opportunities for collaboration.
About The PI
Dr. Karthigeyan Dhanasekaran
Assistant Professor
Centrosome and Cilia biology lab

  • BVSc & AH, Madras Veterinary College, Chennai, 1999-2005
  • MVSc (Molecular Biology and Biotechnology), GBPUAT, Pantnagar, 2005-2007.
  • PhD (Molecular Biology and Genetics), JNCASR, Bangalore,2007-2013.
  • Post-doctoral Research at the Yale School of Medicine, USA, 2015-2020.
  • Assistant Professor at the RCB, Faridabad since 2020.
  • Ramalingaswami Fellow since 2021.
Cutting-Edge Research
Our research interests lie in understanding the perturbation of centriole based organelles across varying disease states that contribute to the pathobiological manifestations and how best to intervene them to restore the physiology. We are trying to understand the centrosome and cilia using high resolution imaging based approaches and focusing on their signalling roles by means of biochemical and molecular cell biology approaches combined with modern proteomics, electron microscopy and super-resolution microscopy based tools.

Centrosome and Ciliary defects

Structural and functional perturbations of Centriolar and Cytoskeletal elements contributing to disease pathology.

Centriolar Signalosomes

Signalosomes operating across centrosome and ciliary basal bodies in infection and ageing.

Centriolar DNA damage response.

Centrosomal response in sensing and responding to DNA damage.


Cytoskeletal Rearrangement

Mechanisms leading to cytoskeletal rearrangements during viral infection.

Centrosome Amplification

Cause and effects of supernumerary centrosomes.

Non canonical role of Aurora A Kinase

Extra mitotic role over the centrosome.


Himanshi Amita

PhD Scholar SRF

Exploring centrosome targeting mechanism of RNA viral proteins and studying the centriolar perturbations in the infected host cell using molecular and cellular approaches. Apart from research I like to draw mandala art in my free time.

Manish Yadav

PhD Scholar JRF

Investigating the mechanism underlying centriolar and cytoskeletal dynamics during RNA viral infection. In my Free time I enjoy playing cricket and the Joy of the Open Road! A New Car Experience.

Sanyami Jain

PhD Scholar JRF

Working to understand DNA damage response in the context of centrosome, with a focus on the role of Aurora kinase A in this process, using molecular and cellular approaches. When I'm not in lab, I enjoy baking, reading and watching movies.

Anshulika

PhD Scholar JRF

Investigating the role of centrosome and cilia in Parkinson's disease. Beyond the lab, I find joy in solving puzzles, painting and while immersing myself in Hindi novels.


Pranay Dudhe

Technical Support for Bio-Imaging

Contributing to the cutting-edge field of Super-resolution imaging, facilitating breakthroughs in understanding cellular structures and dynamics, by employing innovative methodologies and image processing. I have a deep passion for photography, cooking, and swimming, and indulging in the world of movies is another source of joy for me.

Ayushi Bhati

PhD Scholar JRF

Ciliary dynamics in disease and health.

Sanjay Kumar

Lab Assistant

I enjoy playing Volley ball and Cricket after work.

Ajay Jhakad

MS-Int PhD

Microtubule dynamics in RNA viral infections. Outside the lab, I enjoy playing cricket and badminton.


 

First student joining

Himanshi joins the team initiating our Flaviviral study

5/4/2021
 

Zidhan joined our team

Kick starts the viral cell biology in our team

1/2/2022
 

Time 3

Tulasiram Joined our team for an exciting gene editing role

28/11/2022
 

Manish Joins CHIKV project to pursue his PhD & Pranay joins our team with great passion

3/10/2023

Farewell to Zidhan

Ends on a high note with some novel observations documented beyond mere discovery.

30/4/2024

Farewell to Tulasiram

One more long-term association that will be remembered by the team in future.

31/1/2025
 

Sanyami Receives the EMBO SEG fellowship today

She will be collaborating with Astbury Centre - University of Leeds for this fellowship.

5/11/2026

Siddik Shaikh

Project Assistant

Ciliary dynamics in disease and health. In my free time, I enjoy listening to music.

Tulasiram Mora

Project Assistant

Designing tools to explore centrosomes and beyond using gene editing and stable cell line generation. Apart from science, I like to watch movies.

Aparna Upadrasta

Project JRF

Molecular signatures defining centrosome localization and retention using molecular and proteomic approaches. I like to spend my free time solving Sudoku, keeping up with world geopolitics and learning Carnatic music if I'm not in the lab.

Neha Sharma

Project Assistant

Understanding the contributions of liquid-liquid phase separation (LLPS) in centrosome targeted proteins during ageing and infection. I like expressing myself through writing.


Siddik Shaikh

Project Assistant

Ciliary dynamics in disease and health. In my free time, I enjoy listening to music.

Tulasiram Mora

Project Assistant

Designing tools to explore centrosomes and beyond using gene editing and stable cell line generation. Apart from science, I like to watch movies.

Aparna Upadrasta

Project JRF

Molecular signatures defining centrosome localization and retention using molecular and proteomic approaches. I like to spend my free time solving Sudoku, keeping up with world geopolitics and learning Carnatic music if I'm not in the lab.

Neha Sharma

Project Assistant

Understanding the contributions of liquid-liquid phase separation (LLPS) in centrosome targeted proteins during ageing and infection. I like expressing myself through writing.




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  • REGIONAL CENTRE FOR BIOTECHNOLOGY, 3rd Milestone, Faridabad - Gurgaon Road, Faridabad, Haryana, India
  • CCB LAB, Dept of Cancer & Cell Biology
  •  Mon-Fri - 08:00-19:00